This study was performed to examine whether the AF4/FMR2 family, member 1 (AFF1) rs340630 polymorphism is involved in the genetic background of rheumatoid arthritis (RA) in a Chinese population. Two different study groups of RA patients and controls (328 RA patients and 449 healthy controls in the first study group; 232 RA patients and 313 controls in the second study group) were included in our study. Overall, there was no significant difference in either genotype (P=0.71 and 0.64 in the first and second study group, respectively) nor allele (in the first study group: A vs G, P=0.65, OR=1.05, 95%CI=0.85–1.29; in the second study group: G vs A, P=0.47, OR=1.10, 95%CI=0.86–1.40) frequencies of AFF1 rs340630 polymorphism between RA patients and controls. Our study represents the first report assessing the association of AFF1 rs340630 polymorphism with RA risk. No significant evidence was found for the dominant or recessive models. Further case-control studies with larger sample sizes and fine-mapping studies are needed to clarify the role of AFF1 in the genetic basis of RA.

Reaction of [MoO2(acac)2] (where acac = acetylacetonate) with two similar hydrazone ligands in methanol yielded two water coordinated mononuclear molybdenum(VI) oxo complexes with general formula [MoO2L(OH2)], where L = L¹ = N'-(2-hydroxy-3-methoxybenzylidene)-2-methoxybenzohydrazide (H2L¹), and L = L² = N'-(3-ethoxy-2-hydroxybenzylidene)-2-methoxybenzohydrazide (H2L²). Crystal and molecular structures of the complexes were determined by single crystal X-ray diffraction method. All of the investigated compounds were further characterized by elemental analysis and FT-IR spectra. Single crystal X-ray structural studies indicate that the hydrazone ligands coordinate to the MoO2 cores through enolate oxygen, phenolate oxygen and azomethine nitrogen. The Mo atoms in both complexes are in octahedral coordination.

Two new end-to-end azido-bridged polymeric copper(II) complexes, [CuL¹(µ13-N3)Jn (1) and [CuL²(µ13-N3)Jn (2), where L¹ and L² are the monoanionic form of 5-methoxy-2-[(2-methylaminoethylimino)methyl]phenol and 4-chloro-2-[(3-dimethylaminopropylimino)methyl]phenol, have been prepared and structurally characterized by elemental analysis, IR spectra, and single crystal X-ray determination. Complex (1) crystallizes in the orthorhombic space group P2(1)2(1)2(1), with unit cell dimensions a = 7.6651(9) Å, b = 8.3213(9) Å, c = 20.149(2) Å, V = 1285.2(2) A³, Z = 4, R1 = 0.0296, and w׳R2 = 0.0697. Complex (2) crystallizes in the orthorhombic space group Pbca, with unit cell dimensions a = 10.353(1) Å, b = 13.069(2) Å, c = 22.265(2) Å, V = 3012.6(7) A³, Z = 8, R1 = 0.0400, and w׳R2 = 0.1014. Each Cu atom in the complexes is in a square pyramidal coordination, with three donor atoms of the Schiff base ligand and one azido N atom defining the basal plane, and with another azido N atom occupying the apical position. The Cu-Cu distances are 5.173(2) Å in (1) and 5.277(2) Å in (2). Hydrogen bonds can influence the bridging mode of the azide ligand.